Due to concerns of local citizens regarding the problems of domestic violence, the Center began in 1981 as a safe-place in the basement of the Spanish Methodist Church, it was known as the Alpine’s Women’s Shelter. In June 1982, the Center became a separate organization, incorporating as a Texas non-profit corporation in May 1983. Services were expanded with funding from the Department of Human Services, Victims of Crime Act (VOCA), Hogg-Meadows Foundation, Bowers Foundation, and other private donors to victims of domestic violence, sexual assault, and personal injury crimes in the five counties of Brewster, Jeff Davis, Pecos, Presidio, and Terrell under the name: Rio-Pecos Family Crisis Center. In 1993, the name was changed to the Family Crisis Center of the Big Bend, Inc. (FCCBB).

In 1998, the agency purchased an office across from the elementary school on 5th Street as its headquarters. The Meadows, Abell-Hangar, and Swalm Foundations generously donated funds to allow this purchase. The Sul Ross State University Industrial Arts department assisted the mission by building a new thrift store in Alpine. This store currently operates at 202 N. Phelps Street.

In 1998, the FCCBB further expanded services and rented an office and shelter in Presidio County. In 2000, Mary Stringfellow donated the building in memory of her husband, Charles. In 2003, a larger building was purchased in Presidio for use as office space and consulting rooms. There is also a three-bedroom shelter that is maintained in Presidio. In addition, in the summer of 2003, the FCCBB opened a satellite office in Terlingua, South Brewster County, that is presently operated by two crisis specialists. After over 41 years of service, the Center serves, on average, more than 1,300 clients annually. More than 150 local citizens have served on the Board of Directors.

In 2023, the FCCBB purchased the much larger Alpine Community Center building in hopes of renovating the building for use as office and shelter space. With generous donations from the Permian Basin Area, Mabee, F. Marie Hall, Hendershott, Yarborough, and Potts and Sibley Foundations as well as numerous local donors, construction began in January 2024, with an expected completion date of Summer 2025.

In January 2024, the FCCBB acquired the TRAX Transportation Program, which provides cost-effective transportation to the general public in the five counties of Brewster, Jeff Davis, Presidio, Culberson, and Hudspeth.